The fatty acid with the most direct anti-inflammatory activity in the omega-3 spectrum. It competes with arachidonic acid (omega-6) for cyclooxygenase and lipoxygenase enzymes, reducing the production of pro-inflammatory prostaglandins and leukotrienes. It is the precursor to E-series resolvins, which actively trigger the resolution of inflammation (not just stop it).
Documented effects: reduction of serum triglycerides, modulation of mood-associated inflammation (depression/anxiety), endothelial protection, and improved post-exertion muscle recovery.