Vitamins D3 + K2
Vitamins D3 + K2
Vitamins D3 + K2
Vitamins D3 + K2
Vitamins D3 + K2
Vitamins D3 + K2
Vitamins D3 + K2
Vitamins D3 + K2
Vitamins D3 + K2
Vitamins D3 + K2
Vitamins D3 + K2
Vitamins D3 + K2
Vitamins D3 + K2
Vitamins D3 + K2

Bones + Immunity + Energy

Vitamins D3 + K2

4,000 IU of cholecalciferol with K2 MK-7 to ensure calcium reaches its proper destination.

  • Denser bones — calcium reaches its proper destination
  • Protected arteries — K2 MK-7 prevents calcified deposits
  • Better cardiovascular health — lower triglycerides, more stable blood pressure
  • Strengthened immune system — D3 activates antimicrobial peptides
  • Improved mood — D3 modulates serotonin synthesis
  • True therapeutic dose — 4,000 IU, the level shown in studies.

Cholecalciferol D3 (the form your body produces) + K2 in the form of MK-7 (72h in blood vs. 4h for MK-4). Manufactured in Spain.

Vitamins D3 + K2
Vitamins D3 + K2
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€25,95
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For anyone who spends few hours in the sun, lives in latitudes with low UVB radiation in winter, or has low levels in blood tests (less than 30 ng/ml). Especially relevant during perimenopause, menopause, prolonged winter, or with a compromised immune system.

1 capsule daily with food. D3 is fat-soluble: it is better absorbed with fat. Take it with breakfast or your main meal, preferably accompanied by a source of fat (avocado, olive oil, egg). Minimum recommended protocol: 3 months.

6-8 weeks: visible change in serum 25-OH-D levels in analysis. Before that: improved mood and energy, especially if starting from a deficiency. Bone and arterial health progressively and structurally improve.

Active Ingredients 1 capsule *%NRV
Vitamin D3 (cholecalciferol) 100 µg / 4,000 IU 2,000%
Vitamin K2 (menaquinone-7, MK-7) 75 µg 100%
*%NRV: Nutrient Reference Value.

Essential Guide

How to choose a quality vitamin D supplement

The question isn't whether to take vitamin D. It's what form, what dose, and why it's essential to include K2. These are the 4 criteria that make all the difference.

D3 (cholecalciferol), Not D2 (ergocalciferol)

Vitamin D2 is synthetic and of plant origin. D3 (cholecalciferol) is the form your skin produces when exposed to the sun and has significantly higher bioavailability. It is the form that most efficiently raises serum levels and the one used in all intervention studies with results on immunity and bone health.

Therapeutic, Not Preventative, Dose

1,000 IU is a maintenance dose for people with already optimal levels. Most adults in Spain have vitamin D deficiency, especially from October to April. Intervention studies showing real benefits for immunity, mood, and bone health use doses between 2,000 and 4,000 IU daily. 4,000 IU is the daily tolerable upper intake level established by the EFSA for healthy adults.

K2 as MK-7, not MK-4

MK-4 has a blood half-life of about 4 hours. MK-7 remains active for approximately 72 hours, ensuring sustained activation of K2-dependent proteins with a single capsule daily. MK-7 also has higher oral bioavailability. The difference is significant: with MK-4, you would need to take the supplement multiple times a day to maintain active levels.

Why take D3 with K2 (the most searched question)

Vitamin D3 increases intestinal calcium absorption, which can increase by up to 30-40%. The problem is that this extra calcium needs to be directed. K2 activates two key proteins: osteocalcin, which binds calcium to the bone matrix, and matrix Gla protein (MGP), the most potent known inhibitor of arterial calcification. Taking high-dose D3 without K2 can raise calcium levels without controlling its destination.

Who This Is For

Do you have low energy in winter and suspect vitamin D has something to do with it?

Living in a latitude where the sun from October to April does not produce vitamin D. Spending most of the day indoors. A diet poor in vitamin D (little animal fat, little oily fish, few eggs). Lab tests show levels below 30 ng/ml. It is the most prevalent nutritional deficiency in Spain and one of the most ignored.

Vitamin D is not just for bones. It modulates the immune system, regulates serotonin synthesis, activates antimicrobial peptides, and participates in hormonal signaling. And without K2, a high dose of D3 can do more harm than good by directing calcium to the wrong place.

Lifestyle · Silent inflammation

D3+K2 is for you if:

  • You have low vitamin D levels in your blood work (less than 30 ng/ml)
  • You notice fatigue, mood swings, or increased susceptibility to infections in winter
  • You are in perimenopause or menopause and want to protect your bone density
  • You work indoors and get little sun exposure
  • Your diet is poor in vitamin D: little animal fat, little oily fish, few eggs
  • You take vitamin D alone and want to ensure that calcium reaches your bones and not your arteries
  • You want to boost your innate immunity with clinical evidence behind it

Consult your doctor before if:

  • You have hypercalcemia or urolithiasis (calcium kidney stones)
  • You take warfarin-type anticoagulants: K2 can interfere with their effect
  • You have sarcoidosis or other granulomatous diseases: these increase sensitivity to vitamin D
  • You take medication that affects the absorption of fat-soluble vitamins

The mechanism

How does it work?

Two vitamins. Two complementary roles. One orchestrates the calcium that enters, the other decides which tissue it goes to.

Mecanismo  01

Active D3: Absorption, Immunity, and Serotonin

Vitamin D3 (cholecalciferol) enters the body as a prohormone. It is converted to 25-OH-D in the liver and then to 1,25-OH-D (calcitriol) in the kidney. Calcitriol activates receptors in almost all body tissues.

Three main effects: it increases the intestinal absorption of calcium and phosphorus, activates the synthesis of cathelicidin and defensins (antimicrobial peptides of the innate immune system), and modulates the expression of the TPH2 gene that controls serotonin synthesis in the brain.

Magnesium is the cofactor for the hydroxylase enzymes that make both conversions possible. Without adequate magnesium, D3 is not efficiently activated. That's why Triple Magnesium and D3+K2 are combinations that make sense together.

Mecanismo  02

K2 directs: bone and arteries

K2 is an essential cofactor for gamma-carboxylation, a process that activates two key proteins. Osteocalcin, once activated by K2, incorporates calcium into the bone matrix, increasing bone density and strength. Matrix Gla protein (MGP), once activated by K2, inhibits the calcification of arterial walls: it is the most powerful known vascular protective mechanism against calcium-induced arterial calcification.

Without active K2, osteocalcin and MGP remain inactive. The calcium absorbed thanks to D3 does not find a protein to direct it to the bone or remove it from the arteries.

Detail · Take with healthy fat

Usage Protocol

How to Take It

1 capsule daily with your main meal. D3 is fat-soluble: its absorption significantly improves in the presence of fat. Taking it with breakfast or lunch, with a fat source (olive oil, avocado, egg, fish), optimizes its bioavailability.

The minimum recommended protocol is 3 months to see changes in serum levels. Ideally, a blood test should be done before starting and another at 3 months to assess individual response.

If you combine it with Triple Magnesium

Magnesium is an essential cofactor for D3 activation. The combination ensures that the D3 → calcitriol conversion is efficient.

If combined with Omega 3

D3 is fat-soluble. The fatty acids in Omega 3 improve its intestinal absorption. A combination that mutually enhances each other.

What you'll notice

What will you notice?

First 2-4 weeks
Energy and mood
If the starting point was deficiency, the improvement in energy and mood is usually the first thing noticed. D3 modulates serotonin synthesis and circadian rhythm regulation.
4-8 weeks
Boosted immunity
Activation of cathelicidin and defensin synthesis strengthens the innate immune response. Fewer infections, faster recovery.
6-10 weeks
Normalized serum levels
With 4,000 IU daily, blood 25-OH-D levels reach the optimal range (40-60 ng/ml) in most adults during this period. The lab results confirm this.
3 months and up
Bone health and vascular protection
K2 MK-7 progressively activates osteocalcin and MGP. Its effects on bone density and arterial protection are structural and are consolidated with continued use.

Results correspond to clinical studies of each ingredient. Individual results may vary.

Composition

What does each ingredient do?

Two vitamins. One coordinated mechanism. Without one, the other doesn't reach its full potential.

The form of vitamin D that your skin produces when exposed to UVB light. It functions as a prohormone: the body converts it into 25-OH-D in the liver and then into calcitriol (the active form) in the kidneys. Calcitriol binds to receptors present in almost all body tissues and modulates the expression of over 200 genes.

Documented effects: calcium and phosphorus absorption (bone health), activation of cathelicidin and defensins (innate immunity), modulation of the TPH2 gene (serotonin synthesis), regulation of circadian rhythm and hormonal function.

Clinical evidence

Holick (2007, New England Journal of Medicine) — classic review on vitamin D deficiency and consequences. Martineau et al. (2017, BMJ) — meta-analysis of 25 trials (11,321 participants): vitamin D supplementation reduces the risk of acute respiratory infection in people with deficiency.

Clinical evidence

Clinically Proven Results

Two vitamins. Independent evidence published in the most cited medical journals.

Vitamin D3 — Martineau et al., BMJ, 2017

11.321Participants · 25 trials

Meta-analysis of 25 Randomized Controlled Trials

Vitamin D supplementation significantly reduces the risk of acute respiratory infection in deficient individuals. The protective effect is greater in individuals with baseline deficiency (less than 25 nmol/L), where the most significant risk reduction is observed.

  • Significant reduction in the risk of acute respiratory infection
  • Greater effect in people with baseline vitamin D deficiency
  • Consistent results in healthy adult populations and those with comorbidities

Vitamin D3 — Holick, New England Journal of Medicine, 2007

200+Modulated genes

Classic review on vitamin D deficiency and its systemic consequences

D3 (cholecalciferol) significantly raises serum levels more efficiently than D2 (ergocalciferol). Calcitriol activates VDR receptors present in almost all body tissues and modulates the expression of over 200 genes involved in immunity, bone metabolism, and hormonal function.

  • D3 (cholecalciferol) surpasses D2 (ergocalciferol) in bioavailability and efficacy
  • Deficiency is an underdiagnosed cause of fatigue, musculoskeletal pain, and increased infectious susceptibility
  • Modulation of innate immunity via cathelicidin and defensins

Vitamin K2 MK-7 — Knapen et al., Osteoporosis Int., 2013

3 yearsFollow-up · 244 women

Randomized, double-blind trial in healthy postmenopausal women

Three years of MK-7 supplementation (180 mcg/day) showed a significant reduction in bone density loss in the lumbar spine and femoral neck, as well as improved bone strength and a reduction in typical postmenopausal decline.

  • Reduced bone density loss in the lumbar spine and femoral neck
  • Significant improvement in bone strength and reduction of fragility
  • Sustained activation of osteocalcin and matrix Gla protein (MGP)

Results correspond to the clinical studies of each ingredient. Individual results may vary. D3+K2 is not a medicine or a substitute for medical treatment.

Andala Protocol

Recommended combinations

D3+K2 works best when the metabolic environment favors its absorption and activation. These are the products that have been documented to enhance its effect.

Suplemento Triple Magnesium Andala — combinación con Omega 3 EPA DHA de alta concentración

+ Pairs with

Triple Magnesium

The Cofactor Nobody Mentions

Magnesium is an essential cofactor for the two hydroxylase enzymes that convert D3 into its active form in the liver and kidneys. Without sufficient magnesium, conversion is inefficient even if the D3 dose is correct. It is the most underrated combination in supplementation.

Suplemento DeBloat Andala — combinación con Omega 3 EPA DHA de alta concentración

+ Pairs with

DeBloat

D3 is absorbed in the small intestine

Vitamin D3 is fat-soluble and absorbed in the small intestine. An inflamed or dysbiotic gut reduces the absorption of fat-soluble vitamins. DeBloat reduces gut inflammation and balances the microbiota. The result is better assimilation of D3 and any other supplements you take.

Suplemento Omega-3 Andala — combinación con Omega 3 EPA DHA de alta concentración

+ Combines with

Omega 3

The optimal vehicle for D3

D3 is fat-soluble. Its absorption significantly improves in the presence of quality fats. The EPA and DHA fatty acids from Omega 3 are the optimal vehicle to maximize D3 bioavailability, in addition to acting synergistically on systemic inflammation and cardiovascular health.

Suplemento Cortisol Calm Andala — combinación con Omega 3 EPA DHA de alta concentración

+ Combines with

Cortisol Calm

Stress blocks D3 activation

Chronically elevated cortisol inhibits the enzymes that convert D3 into its active form. If you experience winter blues with a component of chronic stress, Cortisol Calm acts on the HPA axis and releases the block that cortisol imposes on vitamin D activation.

FAQ

Frequently asked questions

Vitamina D3+K2 — compatible en ambas etapas, consultar médico. La vitamina D es esencial tanto durante el embarazo como la lactancia para la madre y el bebé. Sin contraindicaciones conocidas a dosis normales. Consulta con tu médico para ajustar según tus niveles.

Vitamina D3+K2 es compatible en ambas etapas, consultar médico.

La vitamina D es esencial tanto durante el embarazo como la lactancia para la madre y el bebé. Sin contraindicaciones conocidas a dosis normales. Consulta con tu médico para ajustar según tus niveles.

Disclaimer: The information on this page is for educational and informational purposes only. Supplements are not a substitute for a varied diet or medical treatment. Consult with a healthcare professional before starting any protocol if you have pre-existing diagnosed conditions.

Your complete protocol
Triple Magnesium

Triple Magnesium

From 29,66€
32,95€ From 29,66€
The Cofactor D3 Needs

Without enough magnesium, D3 is not efficiently
converted into its active form.
Triple Magnesium provides the three most
bioavailable forms and enhances vitamin D
activation from the liver.

Omega-3

Omega-3

From 31,46€
34,95€ From 31,46€
The fat that optimizes D3 absorption

Vitamin D3 is fat-soluble. Omega-3 fatty
acids are the optimal vehicle for its intestinal
absorption. In addition, they act synergistically
on inflammation and cardiovascular health.

DeBloat

DeBloat

From 33,26€
36,95€ From 33,26€

Reduce inflammation for better absorption

An inflamed gut absorbs fat-soluble
vitamins less effectively. DeBloat reduces gut inflammation and improves the assimilation of D3 and any other supplements in your protocol.

Start your protocol

The calcium that enters has a destination.

D3 absorbs. K2 directs. One capsule a day for 3 months to start seeing a change in lab results and energy.

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Medical Notice

The information contained on this page is strictly for educational and informational purposes. Food supplements should not be used as a substitute for a balanced and varied diet or a healthy lifestyle. In the case of pre-existing conditions, pregnancy, breastfeeding, or taking prescribed medication, it is mandatory to consult a healthcare professional before starting any supplementation.